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简亚军
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个人简介


20037月毕业于西北大学化学系化学基地班,获得理学学士学位。2009年七月毕业于中国科十大网赌网站上海有机化学研究所,获得理学博士学位。2010年至2015年于印第安纳大学-普渡大学联合分校从事博士后研究工作。20158月年入十大网赌网址化学化工十大网赌网站工作。
  
本人博士期间发展了一种过渡金属参与的,高效的构建手性炔-联烯结构单元的方法并成功地将其运用于一系列线性天然联烯产物的合成。博后期间,主要从事DNA的损伤与修复研究:对于5,6-C=C双键被饱和的嘧啶类损伤如何形成,以及这类损伤如何引发DNA断链做了系统性地研究;同时参与了金属酶SPL对于DNA损伤SP的的修复研究。
  
目前的研究兴趣为DNA在金属有机化学中的应用



代表性成果


1. Jian, Y.; Lin, G.; Chomicz, L.; Li, L. “Reactivity of Damaged Pyrimidines: Formation of a Schiff base intermediate at the glycosidic bond of saturated dihydrouridine”, J. Am. Chem. Soc. 2015, 137 (9), 3318-3329.
2. Jian, Y.; Ames, D. M.; Ouyang, H.; Li, L. “Photochemical reactions of microcrystalline thymidine”, Org. Lett. 2015, 17(4), 824-827.
3. Lin, G.; Jian, Y.; Ouyang, H.; Li, L. “An unexpected deamination reaction after hydrolysis of the pyrimidine (6-4) pyrimidone photoproduct” Org. Lett., 2014, 16(19), 5076-5079.
4. Lin, G.; Jian, Y.; Dria, K. J.; Long, E. C.; Li, L. “Reactivity of Damaged Pyrimidines: DNA Cleavage via Hemiaminal Formation at the C4 Positions of the Saturated Thymine of Spore Photoproduct and Dihydrouridine”, J. Am. Chem. Soc., 2014, 136, 12938-1294.
5. Ames, D. M.; Lin, G.; Jian, Y.; Cadet, J.; Li, L.. “Unusually large deuterium discrimination during spore photoproduct formation”, J. Org. Chem., 2014, 79 (11), 4843–4851. (chosen as a featured article by editor)
6. Singh, I.; Jian, Y.; Li, L.; Georgiadis, M. M. “The structure of an authentic spore photoproduct lesion in DNA suggests a basis for recognition” Acta Cryst., 2014, D70, 752–759.
7. Jian, Y.; Li, L. “Chemical syntheses of oligodeoxyribonucleotides containing spore photoproduct - a special thymine dimer” J. Org. Chem. 2013, 78, 3021-3029.
8. Yang, L.; Lin, G.; Nelson, R. S; Jian, Y.; Telser, J.; Li, L. “Mechanistic Studies of the Spore Photoproduct Lyase via a Single Cysteine Mutation”, Biochemistry, 2012, 51, 7173–7188.
9. Jian, Y.-J.; Wu, Y.-K. “The enantioselective total synthesis of nemotin”. Org. Biomol. Chem. 2010, 8, 811-821.
10. Jian, Y.-J.; Wu, Y.-K. “Synthesis of the structure proposed for the natural allenic antibiotic scorodonin”. Org. Biomol. Chem. 2010, 8(8), 1905-9.
11. Jian, Y.-J.; Wu, Y.-K. “On the structure of penipratynolene and WA”. Tetrahedron 2010, 637-640.
12. Jian, Y.-J.; Wu, Y.-K. “Insighs into the conversion of propagylic tosylates into bromoallenes.” Synlett 2009, 3303-3306.
13. Jian, Y.-J.; Tang, C.-J.; Wu, Y.-K. ‘‘Enantioselective Total Synthesis of Phomallenic Acid C”. J. Org. Chem. 2007, 72, 4851-4855.
14. Jian, Y.-J.; Wu, Y.-K.; Li, L.; Lu, J. ‘‘An expeditious route to the antipode of harzialactone A”. Tetrahedron: Asymmetry 2005, 16, 2649–2651.